Transfection efficiency vs. cytotoxicity — ranked
Our composite scoring function weights predicted hepatocyte transfection efficiency, endosomal escape rate, and cytotoxicity margin to produce a bench-ready top-10 candidate list.
One score, three physics inputs
The Hit Ranking score (HRS) combines three orthogonal predictions into a single interpretable metric. Weights are tunable per program based on your route of administration and safety profile.
| Rank | ID | TE score | CC50/EC50 | ESR | HRS |
|---|---|---|---|---|---|
| #1 | FE-0042 | 0.91 | 18.4 | 0.82 | 0.893 |
| #2 | FE-0117 | 0.88 | 16.9 | 0.80 | 0.871 |
| #3 | FE-0058 | 0.86 | 21.2 | 0.75 | 0.854 |
| #4 | FE-0203 | 0.84 | 14.7 | 0.78 | 0.832 |
| #5 | FE-0301 | 0.82 | 19.1 | 0.71 | 0.814 |
HRS = 0.50×TE + 0.30×Safety + 0.20×ESR. Top-3 recommended for bench synthesis.
What you get from Hit Ranking
Ranked candidate list
Top-10 formulations sorted by HRS with parameter breakdown for each score component. JSON + PDF report formats.
Efficiency/toxicity plot
Interactive scatter visualization of all 10,000 candidates with top-10 highlighted. Export as SVG or PNG.
Synthesis protocol sheet
For each top candidate: molar ratio, ethanol injection parameters, microfluidic channel geometry recommendations.
Get your bench-ready top-10 list
We run the screen, rank the hits, and hand you candidates ready for synthesis — no formulation expertise required on your side.