The Platform

From design space to IND-ready formulation

Three integrated modules address the three major bottlenecks in LNP delivery development — formulation design, candidate prioritization, and regulatory documentation.

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Modules

Each module solves a specific bottleneck

Use one module or all three as an integrated pipeline. Each produces outputs that feed directly into the next stage.

Formulation Engine

Physics-informed model screens 10,000 ionizable lipid and excipient combinations. Predicts pKa, encapsulation efficiency, particle size distribution, and membrane fusion propensity before any bench synthesis.

Module details

Hit Ranking

Multi-objective scoring engine ranks candidates by hepatocyte transfection efficiency vs. cytotoxicity tradeoff. Incorporates ApoE corona prediction, serum stability, and endosomal escape propensity in the composite score.

Module details

IND Workflow

Structures validated formulation data into IND Module 3 CMC format. Auto-generates analytical characterization tables, stability assessment sections, and proposed formulation specifications.

Module details
How It Works

Four steps from target profile to IND data package

Abstract visualization of computational biology pipeline showing molecular data flowing through analysis stages
01

Upload target tissue profile

Define your target cell type, route of administration, desired payload size, and any known safety constraints. Takes 15 minutes via web interface or API.

02

Run in silico screen

Formulation Engine queries 10,000+ LNP variants against your profile. Runtime 4–8 hours. All computation is asynchronous — you receive a notification when results are ready.

03

Review ranked candidates

Hit Ranking scores and ranks candidates by transfection efficiency vs. cytotoxicity tradeoff. Interactive scatter plot and sortable table. Flag candidates for bench validation queue.

04

Export IND-ready formulation report

IND Workflow assembles validated formulation data into Module 3 CMC format. Exports as structured PDF + machine-readable JSON for ELN ingestion.

Integrations

Connects to your existing informatics stack

API-first design. Data in, results out — no manual export/import steps. Works alongside your existing ELN and LIMS systems.

CortexELN
NovaStar LIMS
HelixConnect API
CSV / JSON export
IND Module 3 PDF
REST API

Start your first computational LNP campaign

Upload your target tissue profile. Receive ranked formulation candidates within 72 hours.

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