Safety by Design: Pre-IND Risk Considerations for In Vivo Gene Editing Programs
Genotoxicity, immunogenicity, off-target editing — a framework for building safety considerations into the LNP formulation screening process before animal studies begin.
Resources
Research, publications, and technical resources
Gendelivr's research team writes openly about LNP formulation science, computational screening methodology, and gene editing delivery challenges.
Browse By Type
What's available
Research Blog
Technical articles on LNP biology, formulation strategy, delivery barriers, and computational screening methodology. 12 articles published.
Browse all articlesPublications
Peer-reviewed research contributions from the Gendelivr team. Published in collaboration with academic partner groups.
Coming in 2026Technical Notes
Formulation screening guides, IND documentation checklists, and LNP characterization protocol summaries.
Available with access
Latest
View all 12 articles
Recent articles
Delivering Base Editors: Why Cargo Size Changes Everything
Base editors and prime editors are larger than standard SpCas9 constructs. How larger cargo size reshapes the LNP formulation optimization problem.
Endosomal Escape: The Rate-Limiting Step in LNP-Mediated Gene Delivery
Only ~1-2% of endocytosed LNPs successfully escape to the cytoplasm. This post examines formulation levers that improve escape efficiency.